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Custom Hard Capsules Manufacturing at ESNO Biotech
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Custom Hard Capsules

cGMP & ISO 22000 certified contract encapsulation. Tailored HPMC vegetarian & gelatin capsules with proprietary formulations, low MOQs, and comprehensive analytical COAs.

Manufacturing Expertise

High-Precision Contract Encapsulation for Global Nutraceutical Brands

From single active botanical extracts to complex multi-ingredient mineral formulations, Shaanxi ESNO Biotech Co., Ltd. delivers pharmaceutical-grade hard capsule manufacturing engineered for superior bio-accessibility and international compliance.

Clean-Label Shell Variety

Vegetable HPMC, organic pullulan, and pharmaceutical bovine/porcine gelatin. Free from titanium dioxide, artificial colors, and GMO excipients.

Flexible Size Options (#000–#4)

Full tooling versatility across sizes 000, 00, 0E, 0, 1, 2, 3, and 4. Precision dosing with micro-dosing capabilities down to 100 mg up to 1,200 mg per unit.

Full Regulatory Audit Support

Every commercial batch comes with HPLC/ICP-MS tested COA, heavy metal limits verification, microbiological safety assays, and stability data.

Rapid Pilot to Commercial Scale

Low MOQ private labeling from 100 retail bottles to multi-million capsule automated runs in pharmaceutical-grade ISO Class 8 cleanrooms.

Standard & Custom Formulations

Verified Capsule Formulations Ready for Private Label

Browse our popular encapsulated nutritional supplements. All formulas can be bottled, blistered, boxed, and labeled under your brand identity with custom potencies.

Mood & Energy HALAL Certified
OEM Vitamin B12 Capsules Mood Energy Heart & Brain Supplement

OEM Vitamin B12 Mood & Brain Health Capsules

FOB Price:$2.40 - $2.80 / piece
Min. Order:100 pieces
Dosage Shell:HPMC / Gelatin #0
Sports Nutrition HALAL
Creatine Monohydrate Capsules 3000mg 5000mg

Creatine Monohydrate Capsules (3,000mg / 5,000mg)

FOB Price:$1.20 - $3.50 / piece
Min. Order:100 pieces
Form:200 Mesh Micronized
Organic Herbal USDA / EU / Kosher
Private Label Herbal Supplements 500MG VB12 Capsules

Private Label 500mg Vitamin B12 Botanical Capsules

FOB Price:$2.16 - $2.68 / piece
Min. Order:100 pieces
Purity:Methylcobalamin 99%
Relax & Sleep Chelated Mineral
Private Label Magnesium Glycinate Powder Capsule 400mg 500mg

Magnesium Bisglycinate Capsules (400mg / 500mg)

FOB Price:$1.50 - $3.50 / piece
Min. Order:100 pieces
Type:Fully Reacted Chelate
Liver Support USDA Organic
Milk Thistle Extract Capsules

Milk Thistle Standardized Silymarin 80% Capsules

FOB Price:$1.80 - $3.00 / piece
Min. Order:100 pieces
Standard:Silymarin 80% UV/HPLC
Adaptogen Withanolides 5%
KSM-66 Ashwagandha Root Extract Capsules 500mg

OEM KSM-66® Ashwagandha Root Capsules 500mg

FOB Price:$0.90 - $3.50 / unit
Min. Order:100 units
Active Assay:Withanolides >5%
Nootropic EU Organic
Hericium Erinaceus Mushroom Capsules Lion's Mane

Lion's Mane (Hericium Erinaceus) Extract Capsules

FOB Price:$2.50 - $3.50 / piece
Min. Order:100 pieces
Ratio:Beta-Glucan >30%
Longevity Anti-Aging
OEM NAD Resveratrol Capsules

NAD+ Booster & Resveratrol Synergy Capsules

FOB Price:$1.90 - $3.80 / bag
Min. Order:100 bags
Format:Stand-up Pouch / Bottle
Cognitive Organic Fruiting Body
Private Label Lion's Mane Mushroom Powder Capsule 500mg

Dual-Extracted Lion's Mane Mushroom 500mg Capsules

FOB Price:$1.80 - $3.50 / unit
Min. Order:100 units
Material:100% Fruiting Body
Immune Health Certified Organic
Organic Lion's Mane Mushroom Powder Capsule 500mg

Certified Organic Hericium Erinaceus Vegan Capsules

FOB Price:$1.80 - $3.00 / unit
Min. Order:1 unit (Sample)
Count:60 / 120 count bottles
Immunity Polysaccharides >30%
High Quality Reishi Mushroom Extract Reishi Capsules

Organic Red Reishi (Ganoderma Lucidum) Capsules

FOB Price:$1.80 - $3.50 / piece
Min. Order:500 pieces
Standard:Triterpenes & Polysaccharide
High Bioavailability Pure Glycinate
Magnesium Glycinate Powder Magnesium Glycinate Capsules 500mg

High Absorption Magnesium Glycinate 500mg Capsules

FOB Price:$1.50 - $3.50 / piece
Min. Order:100 pieces
Digestibility:Stomach-Gentle Non-Buffered
Pre-Packaged Amazon FBA Ready
Organic Lion's Mane Mushroom Extract Powder 60 PCS Per Bottle

Turnkey Lion's Mane 60 Count Bottled Supplements

FOB Price:$1.80 - $3.50 / pack
Min. Order:100 packs
Bottle:PET/Amber Glass Sealed
Women's Health Targeted CFU
Compound Lactobacillus Reuteri Probiotics Capsules

Lactobacillus Reuteri HR7 Probiotic Balance Capsules

FOB Price:$2.15 - $2.58 / piece
Min. Order:100 pieces
Potency:20-50 Billion CFU/Serving
Cellular Defense USP Standard
Private Label OEM Acetylcysteine Pure NAC N-acetyl Cysteine Capsules

Pure N-Acetyl L-Cysteine (NAC) 600mg Capsules

FOB Price:$1.60 - $3.80 / piece
Min. Order:100 pieces
Function:Glutathione Precursor
Bone & Heart MK-7 Synergized
OEM Private Label Healthcare Supplements Vitamin D3 VK2 75mcg

Vitamin D3 5000 IU + K2 (MK-7 75mcg) Complex Capsules

FOB Price:$1.90 - $2.50 / piece
Min. Order:100 pieces
Synergy:Calcium & Mag Enhanced
Standard Operating Procedures

End-to-End Capsule Manufacturing Process

Every commercial batch follows our strict cGMP SOPs. View the real verified production milestones implemented inside Shaanxi ESNO Biotech Co., Ltd.'s cleanroom facility.

STEP 01 Raw Material Inspection & Quarantine

Raw Material

Spectroscopic identity verification, botanical assay qualification, and quarantine testing.

STEP 02 Precision Powder Mixing and Homogenization

Mixing

V-cone and three-dimensional blending to achieve 99.8% coefficient of uniformity.

STEP 03 Wet & Dry Pelletizing Granulation

Pelletizing

Dry compaction and fluid-bed granulation ensuring optimal flowability and uniform fill density.

STEP 04 Tableting & Core Formulation

Tableting

Rotary compression lines for multi-layer core formulation and specialty dual-delivery options.

STEP 05 Enteric and Film Coating

Coating

High-efficiency perforated coating drums for moisture barrier, taste masking, and gastro-resistance.

STEP 06 Precision Capsule Filling

Filling

Tamping pin and dosator capsule filling machines with automated weight rejection controls.

STEP 07 Specialty Sphere Pressing

Sphere Pressing

Specialty pellet and micro-sphere beadlet formation for delayed release combinations.

STEP 08 Primary Bottle and Blister Packing

Packing 1 (Primary)

Automated electronic counting, desiccant insertion, induction foil sealing, and child-safe capping.

STEP 09 Labeling and Secondary Packing

Packing 2 (Secondary)

Wrap-around labeling, batch laser coding, tamper-evident shrink sleeve, and unit cartoning.

STEP 10 Export Palletizing and Shippers

Packing 3 (Export)

Heavy-duty corrugated master cartons, moisture-barrier wrap, and seaworthy palletizing.

Cleanroom Infrastructure

High-Throughput Encapsulation & Packaging Machinery

Our workshop houses high-speed automated machinery engineered to minimize downtime, maximize batch uniformity, and prevent cross-contamination.

Pharmaceutical Powder Mixing Machine

Mixing Machine

High-efficiency sanitary stainless steel ribbon & multi-directional motion blenders.

Granulation & Pelletizing Machine

Pelletizing Machine

Controlled mechanical extrusion and wet-mass granulators for optimal flow kinetics.

High Speed Rotary Tableting Machine

Tableting Machine

Automated rotary compression with real-time compression force & ejection sensors.

Intelligent Aqueous & Solvent Coating Machine

Coating Machine

Negative pressure pan-coating with PLC-controlled spray nozzles and air distribution.

Fully Automated Capsule Filling Machine

Filling Machine

Ultra-precise automatic capsule encasing with continuous vacuum cleaning & weight control.

Sachet and Pouch Packing Machine

Packing Machine

Multi-lane stick pack and four-side sachet sealers with nitrogen flushing capabilities.

High Speed Automatic Bottling & Packaging Line

Automatic Packaging

Integrated unscrambler, tablet/capsule counter, induction sealer, and label applicator.

Alu-PVC & Alu-Alu Blister Packing Machine

Alu-PVC Blister Packer

High-barrier tropicalized blister packaging protecting sensitive botanicals from humidity.

Sphere and Specialty Shape Pressing Machine

Sphere Pressing Machine

Proprietary tooling for dense botanical balls, pellets, and customized delivery geometry.

In-House Analytical Rigor

On-Site Quality Assurance Laboratory

Quality isn't inspected in at the end; it's engineered into every step. Our internal analytical laboratory conducts raw material testing, in-process verifications, and complete finished batch releases.

Microbiology Constant Temperature Incubator

Constant Temperature Incubator

Employed for stringent microbiological testing: Aerobic Plate Counts, Yeast & Mold, Enterobacteria, Salmonella spp., and Staphylococcus aureus per USP/EP guidelines.

Precision Drying Box for Moisture Testing

Precision Drying Box

Performs Loss on Drying (LOD) and moisture residue assays, ensuring active powder stability inside hygroscopic HPMC and gelatin shells to prevent brittleness or microbial growth.

High Precision Analytical Electronic Balance

Calibrated Electronic Balance

Four-decimal analytical weighing balances ensuring micrometric accuracy for reference standards, active ingredient titration, and weight variation testing per 100 capsules.

Parameter ESNO Biotech Standard Capabilities Compliance & Verification
Capsule Shell Types Vegetable HPMC (Kosher/Halal certified), Organic Pullulan, Bovine Gelatin, Delayed-Release Enteric Shells USP <2040> / EP standards, Non-GMO project compliant
Available Sizes & Fills #000 (1000–1200mg), #00 (600–850mg), #0 (400–600mg), #1 (300–450mg), #2, #3, #4 Dosing tolerance: ±2.5% automated weight check
Shell Colors & Branding Clear, All-Natural Chlorophyll Green, Custom Pantone Two-Tone, Axial/Radial Logo Printing Titanium Dioxide (TiO2) free available upon request
Finished Packaging Types HDPE Bottles, Amber Glass Jars, Alu-PVC / Alu-Alu Blister Packs, Bulk Carton Polybags, Multi-serving Pouches Induction sealed, tamper-evident neck bands, child-resistant caps
Standard Minimum Order 100 Bottles (Private Label Ready) / 50,000 Capsules (Custom Blend OEM) Factory direct batch pricing, export logistics ready
Quality Release Documents Certificate of Analysis (COA), Allergen Statement, Heavy Metal Report, Microbe Test, BSE/TSE-Free Statement TÜV Rheinland verified facility, ISO 22000, HACCP
Procurement Intelligence

Frequently Asked Questions by Capsule Buyers

Essential details to guide your procurement, formulation formulation, and custom packaging decisions.

What capsule shell options are available for vegan or clean-label brands?

Shaanxi ESNO Biotech Co., Ltd. specializes in clean-label capsule development. We supply USP-grade Vegetarian HPMC (derived from pine wood cellulose), natural plant fermented Pullulan, and delayed-release acid-resistant vegan shells. All vegan shells are non-GMO, gluten-free, allergen-free, Halal and Kosher certified, with 100% Titanium Dioxide (TiO2) free opacity options.

Can you formulate a proprietary capsule blend from our ingredient brief?

Yes. Our in-house R&D team has formulated over 400 unique dietary supplements. Simply supply your target actives, desired potencies, and functional claims (e.g. cognitive support, liver detoxification, athletic energy). We will evaluate powder flowability, bulk density, excipient suitability (such as organic rice flour or silica), produce pilot samples for your evaluation, and scale to commercial production.

What are the lead times for custom capsule production and private labeling?

Stock formulations packaged with custom printed labels can typically be dispatched in 10 to 15 business days. Custom ingredient sourcing, custom encapsulation, and complete bespoke printed blister/box runs typically require 3 to 4 weeks depending on raw material availability and testing protocols.

How does Shaanxi ESNO Biotech Co., Ltd. manage heavy metal and microbiological safety?

Every ingredient undergoes mandatory quarantine and testing via Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for Lead (Pb), Arsenic (As), Cadmium (Cd), and Mercury (Hg) to comply with FDA, USP <2232>, and EU food supplement safety laws. Microbiological integrity is systematically verified in our internal laboratory incubator and verified with third-party reports upon client request.

Can you assist with label design compliance and Amazon FBA preparation?

Yes. We offer turnkey packaging solutions including label layout compliance review (Supplement Facts layout, Net Quantity declarations, allergen advisories), bottle induction sealing, barcoding, shrink banding, master carton drop-testing, and Amazon FBA pallet preparation.

Ready to Manufacture Your Custom Hard Capsule Line?

Get in touch with Shaanxi ESNO Biotech Co., Ltd.'s formulation specialists. Receive batch feasibility feedback, technical specifications, and factory-direct pricing within 24 hours.